Yaroshenko K. Improving complexes diagnostic and medicinal measures in the treatment of bleeding ulcers pyloroduodenal zone

Thesis is devoted to the problem of improving the diagnosis and treatment of patients with bleeding pyloroduodenal ulcers. Refined risk factors of recurrence of ulcer bleeding: increased tumor necrosis factor> 22.4 pg/ml indicates a risk of adverse outcomes flow ulcer bleeding and reduction of 2 or more times during the treatment of tranexamic acid - an indicator of the effectiveness of hemostatic treatment. In the early posthemorrhagic period predictors of recurrent bleeding is increasing TNF > 22.4 pg / ml, pepsinogen -1 > 165 mg/ml, pepsinogen -2 > 35 mg / ml, gastrin > 100 mg / ml. Proven benefits of treatment with high doses of pantoprazole 80 mg/bolus followed by an infusion of 8 mg/hour and tranexamic acid 10 mg/kg/day, by reducing the amount of recurrent bleeding, operations performed at relapse, and overall postoperative mortality.