Milastnaia A. Сomparative estimation of pharmacological properties of nonsteroidal antiinflammatory drugs

The subject: antiinflammatory, analgetics and febrifugal properties of izamben in experimental researches on laboratory animals and dogs. Objective research:to probe febrifugal, antiinflammatory and analgetics action of preparation "Izamben" to probe efficiency of izamben at pathologies of locomotorium of dogs. Test methods: clinical, haematological, biochemical, citological, serum, pharmacological, statistical. Scientific innovation: first complex researches of analgetics are conducted in veterinary medicine, febrifugal and antiinflammatory action of izamben (amizon). At experimental adjuvant arthritis (AA) which is characterized the change of morphometric (expressed edema of extremity) and haematological indexes of inflammation (leykocitozis, increase of erithrocite sedimentation rate (ESR), positive reaction on a C-reactive albumen (C-RA), application of izamben during 14 days provided the expressed antiinflammatory action which showed up absence of C-RA in the whey of blood of rats, by normalization of ESR, approaching of index of amount of leucocytes and morphometric indexes to the level of healthy zoons. A diagnostic algorithm is optimized for differential diagnostics of arthral pathology of dogs on the basis of organoleptical (color, transparency, viscidity, clot of mucin), biochemical (general albumen) and citological indexes of synovia. Degree of implementation:research materials are plugged in "Scientific-praktical recommendations on application of izamben at osteoartrothis of dogs". Application field: veterinary medicine.