Loginova O. Doppler criteria of the ovaries state in vitro fertilization programs among women with a weak ovarian response syndrome.

Research work is devoted to studying and establishment of the most reliable criteria for early diagnosis of underprotocolary high probability of weak ovarian response syndrome in controlled ovarian stimulation protocols at infertility treatment, the development of rational methods of prevention and the development of this syndrome and its treatment. As a result of a comprehensive survey of 109 patients with infertility (35 patients with normal response to the ongoing controlled ovarian stimulation, 38 patients with weak ovarian response syndrome in the anamnesis and 36 patients with a probability of weak ovarian response syndrome) for the first time was determined that the most reliable criteria for a high degree of probability of the possible development of weak ovarian response syndrome in the case of the conventional approaches to the treatment of infertility with the help of in vitro fertilization methods the criteria of Doppler research - resistive index and resistive index is more informative in comparison with hormone (follicle-stimulating hormone, luteinizing hormone, estradiol, antimulleran hormone), hemostasis and ultrasonic methods of research. Identified parameters of pulsatile index and resistive index are higher than those with the normal ovarian responses (control group) in 1.5-2 times or more it is depending on the type of ovaries structure (afollicular and follicular types). For the first time diagnostic value of Doppler research of patients, its criteria - pulsatile index and resistive index, as a promising, high-quality informative diagnostic method in underprotocolary diagnostics of high probability of weak ovarian response syndrome, the diagnostic value of Doppler research which is much better than hormonal, hemostatic and ultrasonic diagnostic methods was proved. In research work the most important anamnestic criteria lead to the development weak ovarian response syndrome are defined. These include the patients' age, transferred surgery on the uterine appendages, disturbances of a menstrual cycle, pregnancy termination. A fundamentally new "modified" treatment protocol of patients with a probability of weak ovarian response syndrome developing, pharmacological constituents which have a positive effect on the different stages of pathogenesis of weak ovarian response syndrome was first developed. The combined effect of drugs "turn off" temporarily ovarian function, improve the rheological properties of blood and blood supply to the ovarian tissue can achieve positive results in overcoming weak ovarian response syndrome.