Stroy D. Complex analysis of the possible association of genetic factors with the risk of cardio-vascular pathology

Dissertation for the candidate of medical science in speciality 14.03.04. - pathological physiology. - Institute of physiology of A. Bogomoletz, Kyiv, 2013. The information regarding the influence of 14 single nucleotide polymorphisms (SNPs) was obtained from children with arterial hypertension in Ukrainian population. It was shown, that SNP MMP9 (C-1562/T) is the most significant predictor among all 14 SNPs and minor allele is associated with the onset of this pathology. The second most important gene polymorphism was NOS3 (Glu298/Asp) and it was also included in the mathematical model. Heterozygous genotype has the protective role and protects from the possible onset of arterial hypertension. With the use of the developed algorithm of the complex genetic data analysis is was shown that these SNPs have main independent effects. The information regarding the influence of 7 SNPs was obtained from patients with myocardial infarction in Ukrainian population. It was shown that SNP MGP (G-7/A) is the most significant predictor of this pathology. Synergetic epistasis with the SNP MGP (Ala83/Thr) was revealed and it was the second most important predictor. The combination of heterozygous genotypes is associated with the increased 2-fold risk of the onset of myocardial infarction and the combination of minor genotypes is associated with the increased 8.3-fold risk of development of myocardial infarction. The algorithm of multidimensional data analysis of the genetic data was proposed and in our consideration it has advantages over the single dimensional data analysis or separate multidimensional data analysis methods.