Balavskij V. Mechanism of pseudohepatorenal syndrome in separation of oxidation and phosphorylation.

Object -theoretical generalization and a new scientific problem solving on early pathogenesis psevdohepatorenal syndrome as the basis of worsening of renal and hepatic failure in separation of oxidation and phosphorylation under the conditions of the administration 2,4 - dinitrophenol; methods - physiopathologycal, biochemical, mathematicaland the results -The thesis presents theoretical generalization and a new scientific problem solving on early pathogenesis psevdohepatorenal syndrome as the basis of worsening of renal and hepatic failure in separation of oxidation and phosphorylation under the conditions of the administration 2,4 - dinitrophenol, this found increasing concentrations of tumor necrosis factor-alpha in plasma, showed higher degree oxidative modification of proteins in the kidney and liver of rats at a rate of R / B and revealed the development of the syndrome of loss of sodium in the urine with an increase in its excretion and clearance. The increase in the concentration of interleukin - 6 in plasma, which showed not only inflammatory but also anti-inflammatory properties as demonstrated by Forest Graphics objective analysis of comparative evaluation of the role of interleukin-6 and tumor necrosis factor-alpha in the syndrome of loss of sodium in the urine conditions for separation of oxidation and phosphorylation. Melatonin by antioxidant, cytoprotectors properties showed a protective effect on the course of psevdohepatorenal syndrome force oxidation and phosphorylation, reduced the loss of sodium and protein excretion, reduced levels of interleukin-1?, increased concentrations of interleukin-6 in plasma and reduced the level oxidative modification of proteins in kidney and liver of rats by inhibition ratio R / B in the proximal, distal nephron, renal papillary collecting tubule and protein masses cytoplasm of hepatocytes.