Pavlenko I. Mechanisms sanogenesis in infusion therapy of severe traumatic brain injur

Object - craniocereberal trauma; the purpose - a pathogenetic substantiation of a choice and efficiency of application of hyperosmolar infusion drugs of correction of infringements of a homeostasis at a heavy craniocereberal trauma; methods - biochemical, mathematical; results - In this paper, an important problem is solved - the definition of the functional state of the organism homeostasis in traumatic brain injury in terms of hyperosmolar infusion of different drugs. We found that patients who received sorbilactum more pronounced positive dynamics: Glasgow scale com exceed 23% (p < 0.05) and Glasgow - Pittsburgh - by 26 % (p < 0.05) values of those in who correction was performed mannitol . Indicators of water and electrolyte metabolism in patients with severe traumatic brain injury in terms of infusion of various hyperosmolar agents do not change significantly (p> 0.05), ranging rules are positive. The level of inorganic phosphorus in the blood plasma, which in 35 % of patients after injury was below normal values , in terms of infusion sorbilactum continue not only decreased, but even increased by 11.5 % times (p < 0.05), while in patients who were administered mannitol, phosphorus level continued to decrease (p < 0.05). Along came a change and the level of ATP in erythrocytes : in the group of patients who were administered mannitol, erythrocyte ATP level continued to decline at 2-3 days (p < 0,05) in patients who were administered sorbilactum tended to increase (p > 0,05). On the basis of our study it was found that the dose used sorbilactum not increase the severity of hyperglycemia (p < 0.05). Influenced sorbilactum not growing and laktatsydemiya that usually occurs in severe TBI. The level of lactic acid in venous blood progressively decreased after 1-2 days after injury (p < 0.05). Sorbilactum infusion significantly reduces the expression of endogenous intoxication, which occurs in severe traumatic brain injury. It is noted more pronounced effect sorbilactum unlike mannitol. In the study of correlations between clinical condition and performance of homeostasis found probable many strong correlation between the age of patients, a scale com Glasgow, a scale Glasgow - Pittsburgh and performance homeostasis in patients under conditions of mannitol infusion on day 3 (p <0.05 ) in patients under infusion sorbilactum - most likely observed weak and medium strength correlation, which weakened to 3 days (p < 0.05). The data demonstrate the effectiveness and feasibility of using sorbilactum infusion therapy in patients with severe traumatic brain injury to reduce swelling of the brain.