Litvin Е. Features of hypertensive encephalopathy in patients with hypothyroidism and pathogenetic substantiation of healthcare in a clinic.

The investigation of clinical and neurological, neuropsychological peculiarities and characteristics of hemodynamic, functional brain activity in patients with hypertensive encephalopathy and concomitant hypothyroidism. The developed scheme of diagnostic criteria HDE with concomitant hypothyroidism in a clinic. The use of neuroprotective therapy in patients with comorbid disorders. The study involved 127 patients, 60of whom had HDE and concomitant hypothyroidism, 37 and 30 HDE were healthy. The complex clinical and neurological, neuropsychological (the scale MMSE, Beck, Spielberger-Hanin), instrumental (UZDG, REEG, Craig), laboratory (complete blood count, lipidohrama, blood test to determine the level of thyroid hormones) researches. The study demonstrated that patiens with HDE and concomitant hypothyroidism in the clinical picture dominated mnemonic, cerebro, vestibular-atactic syndromes, anxiety and depressive disorders are three times more likely than patients without concomitant thyroid disease. Found violations of cerebral blood flow in the form of reduced cerebral reactivity in the common carotid, middle cerebral and vertebral arteries, increas the tone of cerebral arteries concernment of mesodiencephalic structures of the brain, lipid metabolism in patients with concomitant hypothyroidism. The use of neuroprotective therapy (tsytikolinu) in patients with hypothyroidism and concomitant HDE positive effects on the clinical course of comorbid disease, neuropsychological and cerebral hemodynamic parameters.