Yavorskyy V. The Immunological reactivity at the systematic plasma donations

On the basis of immune reactivity indicators for donors without preliminary donor experience and regular donors were determined the frequency and the duration of procedures automated plasmapheresis, which do not cause humoral and cellular adaptive immunity depletion in the organisms of active donors in systematic plasma donation, given the features of the donor population immunity, which characterized by lymphocytosis, depression helper and suppressor units. Supplemented scientific data about immunological reactivity during plasma donations in a long period from 18 months, which provided the plasmapheresis protocols, and its part in maintenance of donors organism homeostasis. It was established, that cellular adaptive immunity is less in active donor without the pronounced donor experience than in the regular donor, in them it does not change. The inhibition of cellular adaptive immunity parameters from baseline values was defined: by 20 % reduce the number of CD4+-lymphocytes and by 27 % the number of CD8+-cells in active donors without preliminary donor experience during systematic donation in period the 6-9 months at the frequency plasma donations more than one procedure for 20 days. The humoral adaptive immunity and cellular nonspecific resistance in active donors without preliminary donor experience increased, but less than in regular donor, the humoral nonspecific resistance increases more than in regular donor; the mainly changes occur within the oscillations physiological parameters. The obtain data reflect not enough formed the compensatory-adaptive reactions in organism active donors without preliminary donor experience and stable - in regular donors. It was determined that during the systematic plasma donation in immune reactions aside from Th1 and Th2, participate and Th17.