Kovalenko L. Pathogenic justification to use of sodium nucleinat for the prophylaxis of chronic inflammation

Thesis is devoted to the pathogenetic justification of the use of sodium nucleinat for preventing chronic inflammation. We used the pathophysiological, hematological, histological, histochemical, cytological, cytochemical and statistical methods. Found that the use of sodium nucleinat in secondary chronic inflammation leads to a reduction in inflamed tissue infiltration by granulocytes during the study period. Infiltration of monocytes and lymphocytes in the earlier periods increases, and at a later date - is reduced, indicating a decrease in chronic inflammation. Changes in the cellular composition of the inflammatory focus on its periphery under the influence of sodium nucleinat correspond to those in the centre, but less pronounced. When inflammation during treatment with sodium nucleate compared with the natural course of the process of leaching occurs more cells from the bone marrow into the blood in the early stages, more pronounced, and at a later date - less pronounced activation of hematopoiesis. Leukocyte response of peripheral blood at an earlier date is expressed more and at a later date - less. Functional activity of peripheral blood neutrophils, according to the activity of marker enzymes downward. Monocytes and lymphocytes in the earlier periods of inflammation above, and at a later date - below. The results indicate the feasibility of using sodium nucleinat for preventing chronic inflammation.