Soloshenko I. Optimization of respiratory support and fluid therapy in preterm infants

125 prematurely newborns, 99 of who were in need of MV concerning respiratory distress syndrome, were examined and treated. The prematurely newborns were divided into observation groups depending on the type of respiratory assistance. 1st group included 66 prematurely newborns who had MV with pressure control, 2nd group - 33 prematurely newborns who were assisted with HFOV respirator. 3d control group included 26 prematurely newborns with slight respiratory disorder, according to WHO (1999), and were able to breathe on their own. It is proved that substantial adverse risk factors of respiratory and hemodynamic disorder development in prematurely newborns are body weight, less than 2000 g at birth (OR = 2,0; p=0,0119), severe asphyxia at birth (OR = 26,5; p=0,0113), asphyxia of moderate grave degree (OR = 7,8; p=0,01180), turgor skin reduction (OR = 18,4;p=0,01162). After the analysis of cerebral circulation patterns in prematurely newborns of control group during the first day patterns of increased resistance were absent. Development of ventilator-associated pneumonia in the 2nd group of children was less frequent 45,5±8,6% vs 81,8±4,7%, (р<0,001) comparing to the 1st group. Frequency development of "air leakage" syndrome was less as well (3,0±0,5% and 16,7±4,5% relatively, р<0,001).