Govsyeyev D. Correction immunological desorders in cervical ectopia destruction.

The work is dedicated to improving the effectiveness of treatment of patients with ectopia of the cervix, by optimizing therapies of this disease by correcting immune and microcirculatory disorders in surgical destruction ectopia. Based on clinical and immunological study of 120 women studied adaptive mechanisms to pathological processes in cervical ectopia. Refined scientific data on clinical, bacteriological, colposcopy, cytomorphological features of the disease, showing that changes in the biological community urogenital range and frequency of detection of opportunistic microorganisms lead to the formation of dysbiosis in women with cervical ectopia. Supplemented scientific data on local microcirculation in patients with ectopia by analyzing the results of laser Doppler flowmetry, including violations observed basal blood flow, the formation of blood stagnation type in 84,4% of patients. It is proved that cervical ectopia occur against the backdrop of disorder in the local and systemic immunity: increasing of leukocytes, superoxide radicals in cervical secretions of patients with ectopia, the development of cytokine imbalance by increasing the level of proinflammatory cytokines in cervical secretions and blood serum. Supplemented with scientific data justify the use of combined therapy with the use of radio-wave surgical treatment of cervical ectopia to optimize the clinical, immunological and hemodynamic parameters were studied in comparative perspective and combined effectiveness of traditional treatments for these patients. The proposed combined therapy allows to quickly normalize reactions of local and systemic immunity to block the processes that lead to autoimmunization and development of autoimmune reactions, shows high efficiency in higher antimicrobial immunity, reduces terms epithelialization and wound repair defect to avoid postoperative complications and relapses, to achieve recovery in 93.5% of patients with cervical ectopia.