Kolesnichenko I. Іmproved methods of treatment of uterine leiomyoma in women of reproductive age.

The dissertation is dedicated to improving the issue of differential treatment of uterine leiomyoma in women of reproductive age. According to research conducted by the peculiarities of etiology, pathogenesis, state and local systemic homeostasis, proliferation markers content and growth factors for uterine leiomyoma and its sonographic characteristics. Established that as the main pathogenesis of uterine leiomyoma in women of reproductive age are the inflammation, proliferation markers, growth factors, hormonal factors, both local and general. Violation levels of receptors and mechanisms of pathogenesis PM interrelated and manifest imbalance in RE and RP dominated the last expression that should be considered when developing new pathogenetic therapies. Installed us mixed changes in leyomiomatoznyh receptor sites in the endometrium may be one reason for ineffective hormonal treatment of patients with comorbidity and serve as justification for surgical intervention. The algorithm staged treatment of uterine leiomyoma in women of reproductive age, depending on the size, location of nodes using selective modulator RP UA for the purpose of preoperative preparation of patients. The advantages of the use of gonadotropin-releasing hormone.