Kryachok Т. The character of interrelations between the pathogenic factors of insulin resistance syndrome in the experimental model

The thesis is devoted to the elucidation of the syndrome insulin resistance proathe-rogenic action, role in it of the systemic inflammation and oxidative stress both as the in-terrelations between the main components of the syndrome – disturbances of lipid, lipo-protein and glucose metabolism. The investigation was performed in 3 groups of rabbits with the syndrome induction by the way, accordingly, chronic glucose loading, chronic lipid loading and chronic sys-temic inflammation. There was determined the existence of the common pathogenic basis as the decline of insulin sensitivity independently of the initiating factors. In all 3 series of experiment was determined the same spectrum of metabolic disturbances on the background of some differences in the magnitude of changes of separate indexes in dependence on the initiat-ing factor. It was shown that blood lipoprotein modification with acquiring by them the abilities of foreign bodies, be captured by macrophages and initiate of the immune re-sponse development is the main mechanism of the insulin resistance syndrome proathero-genic action independently of its initiating factor. These changes were very prominent and were coincided with much less significant traditional factors of atherogenesis, first of all – with moderate hypercholesterolemia. These data mean that the appreciation of the risk of atherosclerosis development can’t be based only on the blood cholesterol level determina-tion and the existence of insulin resistance with the corresponding metabolic disturbances and qualitative changes of blood lipoproteins with acquiring by them proatherogenic abili-yies must be taken into account.