Skliar V. Optimization of anesthesia in children with organic lesions of the central nervous system

The thesis deals with the characteristics of perioperative condition of children with organic disorders of the central nervous system (cerebral palsy and hydrocephalus) against various options to improve anesthesia in these children, taking into account the characteristics of their original state. In the course of work have been established compensatory hemodynamic changes in children with acquired hydrocephalus. Supplemented scientific data on structural and morphological changes of the brain in children with acquired hydrocephalus, whose main feature is the prevalence of signs of periventricular ischemia. Confirmed changes in rates of cerebral blood flow and metabolism in these children as well as by examining correlations between indicators of cerebral blood flow and glucose levels in the cerebrospinal fluid have proven that in children with hydrocephalus levels of glucose metabolism increase independently of the reduction of cerebral blood flow. Shown the influence of sevoflurane in a concentration of 0.6 - 0.8 MAC in children with hydrocephalus in brain metabolism rates and blood flow. Supplemented and generalized anatomical and physiological characteristics of children with cerebral palsy. Refined data on the impact of different options of anesthesia on hemodynamic parameters during surgery in children with central nervous system lesions. Installed the level of stress in children with hydrocephalus and cerebral palsy, and the impact of different options of anesthesia in its value. Improved methods of anesthesia in children with central nervous system lesions by studying various types of anesthesia and their impact on the performance of central and cerebral homeostasis.