Kukhlenko R. Peculiarities of neuropsychological disorders in patients in acute and early recovery period of ischemic stroke

Dissertation is devoted to the peculiarities of pathogenesis of post-stroke neuropsychological disorders, particularly to the investigation of the role of biochemical and immunologic factors in the development of these disorders. Comparative evaluation of diagnostic value of different neuropsychological scales for early depressive disorders determination and evaluation was performed, as well as a number of different clinical and para-clinical factors of its development, influence of depressive disorders on the levels of physical disability and cognitive deficit in patients after primary cerebral ischemic stroke. Data of investigation of 205 patients in the acute and early recovery period of mild and moderate ischemic stroke were taken into consideration. It was revealed that in acute period of ischemic stroke depressive disorders develop in 36 % of patients and in early recovery period - in 42 %. Development of nitrosative stress, changes in cellular immune status, humoral inflammation, including increase of acute inflammatory factors - concentrations of C-reactive protein and interleukin-6, as well as development of endogenous intoxication are characteristic for patients with post-stroke depressive disorders. Development of post-stroke depressive disorders of moderate and severe level in the acute and early recovery period of ischemic stroke was accompanied by the increased level of physical disability and cognitive deficit. Simple prospective comparative clinical study of different treatment regimens suggested combination of paroxetine and cortexin as efficient for the correction of post-stroke depressive disorders.