Lyashenko L. Role of NO-dependent processes in the pathogenesis of periodontium affection in modeled metabolic syndrome

This dissertation is aimed to determine the role of different isoforms of NO-synthases, including nuclear factor ?B-mediated (NF-?B), in the pathogenesis of periodontium tissue affections which develop in white rats under modeled metabolic syndrome (MS). It has been demonstrated the functional activity of neuronal NO-synthase (nNOS) in modeled MS limits free radical processes, collagen lysis and depolymerization of proteoglycans in periodontium tissues. The capability of nNOS to provide down-regulation of products of superoxide anion-radical, lipid peroxidation, collagen lysis and depolymerization of proteoglycans in periodontium tissues in modeled MS is NF-?B-mediated. The research has shown the functional activity of inducible NO-synthase (iNOS) and NF-?B in modeled MS is associated with unidirectional changes in free radical processes in periodontium tissues (superoxide anion-radical hyperproduction, development of decompensated lipid peroxidation, accompanied by exhaustion of antioxidant potential, decrease of catalase activity), resorption of alveolar process, connective tissue disorganization. The research has found out the administration of L-arginine under the conditions of MS suppresses lipid peroxidation in soft tissues of periodontium, enhances antioxidant potential, limits the process of alveolar process resorption, collagen lysis and depolymerization of proteoglycans in soft and bone tissues of periodontium.