Bondarenko O. Effects of N-stearoylethanolamine on the emotionality and learning ability of rats

The research are fundamental because they allow to expand theoretical concepts regarding the role of the member of saturated NAE N-stearoylethanolamine (NSE) in the modulation of innate and acquired behavior of rats. The experimental data of the influence of NSE on the innate and acquired forms of rats' behavior in normal conditions and during chronic alcoholization are represented. It is shown for the first time that the systematic 7-daily administration of NSE changes motor, emotional, anxious-like behavior and learning ability in rats. NSE at a dose of 0,1 and 5 mg/kg during 7 days is able to change the behavior of alcoholised and nonalcoholised rats in different ways, that may indicate the involvement of different neurophysiological mechanisms of influence of both low and high doses of NSE on the behavior of animals. It was found that the administration of NSE in both doses did not affect the motivation of alcohol consumption and did not cause specific adverse effects of cannabinoid drugs on behavioral responses of animals, indicating the advisability of further study of this substance.