Sampara S. Pathogenetic rationale for the use of nitric oxide synthesis modulator for the correction of gestational complications of antiphospholipid syndrome (experimental study)

Object - especially the pathogenesis of the uterus and placenta in animals with obstetric antiphospholipid syndrome, the lungs of fetuses and newborns; purpose - establishing peculiarities of the uterus placenta in animals with obstetric antiphospholipid syndrome, respiratory system and opportunities for their offspring prevent certain pathological changes using preskursora nitric oxide synthesis; methods - biochemical, pathophysiological, pharmacological, pathological, statistics results - during experi-mental studies proved that the obstetric antiphospholipid syndrome a decrease in fertility test animals, accompanied by pathological changes in coagulation, reduced nitric oxide synthesis and violation of prooxidant-antioxidant homeostasis in the placenta and uterus, pathological changes in histological structure with formation of fetus-placental insufficiency; newborn animals from females with obstetric antiphospholipid syndrome in lung tissue marked activation of lipid peroxidation, changes in surface activity of lung extracts, abnormal lung structure; it was found that L-arginineis able to prevent disorders in the system of blood coagulation, increase the viability of offspring, improve the histological structure of uterus, placenta and lungs of fetuses and newborns in obstetric antiphospholipid syndrome; aminoguanidine in this pathology deepens disorders of hemostasis, signs of the uterus, placenta and newborn respiratory system disorders; for the first time demonstrated the feasibility of using the L-arginine as an effective means to improve the fertility, attenuate of pathological changes in the placenta and uterus of mice Balb/c with obstetric antiphospholipid syndrome and prevent the respiratory lesions in their offspring.