Alale A. Causal correction of anaerobic vaginal dysbiosis in preparation for elective caesarean section, and the prevention of septic complications

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U006816

Applicant for

Specialization

  • 14.01.01 - Акушерство та гінекологія

10-12-2015

Specialized Academic Board

01896866

Essay

The thesis for the first time mapped the results of preparation for the planned caesarean section, including the study of quantitative and qualitative characteristics of the spectrum of the microbial vaginal contents, which allowed the status detects vaginal dysbiosis, as a factor of infectious risk abdominal delivery and define the principles of causal its correction. In the study of ecological community have seen the following states: the imbalance of I degree (moderate) - 3 (3.48%), imbalance of II degree (severe) - 83 (96.51%). In the control group the same state ecological community was represented by the imbalance of II degree (severe) in all cases, 30 cases (100%). Depending on the etiological structure of the group of pregnant women studied microbial spectrum of vaginal contents before treatment is estimated as follows: anaerobic - in 19 (22.09%), mixed dysbiosis - 67 (77.91%) and in the control group: anaerobic - at 2 (6.7%), mixed dysbiosis - in 28 (93.3%). Leading obligate anaerobes were - Gardnarella vaginalis (lg 6,10 ± 0,15 cfu / ml), Eubacterium spp. (lg 5,50 ± 0.14 cfu / ml), Atopobium vaginae (lg 5,10 ± 0.17 cfu / ml), Snaethia spp. (lg 4,50 ± 0.18 cfu / ml), Peptostreptococcus spp. (lg 4,70 ± 0.15 cfu / ml). Carried out the correction of vaginal dysbiosis to abdominal delivery significantly improved clinical outcomes and results: uncomplicated postpartum period, active involution of the uterus and vagina normalization of habitat, as reliable indicators show clinical and laboratory examination of women in childbirth. In pregnant women of the control group showed a high frequency of subinvolution uterus - in 14 (46.7%) women in childbirth, clinical and cytological signs of postpartum endometritis - in 16 (53.3%), ie, every second woman in childbirth. Based on the obtained results proved that the study has helped reduce the incidence of postpartum endometritis in pregnant women, as well as improved the results of clinical and laboratory research - improved mikrobnіy range by opportunistic obligate anaerobic mikroorganizmv normotsenoza to have 89.5% of pregnant women . It is proved that in order to prevent post-partum endometritis, necessary in preparation for the planned caesarean section to deepen the diagnosis of microbiocenosis based DNA diagnostics videleny vaginal microbial spectrum, particularly obligate anaerobes.

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