Biletska P. Cord blood derived nucleaar cells usage in experimental neovascular retinopathy treatment.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U000150

Thesis Registration Form

0416U000150.pdf

Applicant for

Specialization

  • 14.01.35 - Кріомедицина

22-12-2015

Specialized Academic Board

Д 64.242.01

Institute of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine

Essay

The research object were the processes locking neovascular retinopathy retina after the injection of cryopreserved cord blood . The research aim was the study of the mechanisms of action of cryopreserved cord blood nucleated cells and human impact on the structural - functional characteristics of the retina of experimental animals with simulated neovascular retinopathy. Research methods : ophthalmologic, histological , morphologic, statistical analysis. .It was showen for the first time that normal retina produces a certain level of pro- and antiangiogenic factors genes in a ratio that remains a balance between angiogenesis activators and inhibitors. In the neovascular retinopathy prevails VEGF gene expression, which triggers a neoangiogenesis cascаde and causes the emergence and spread of newly formed vessels in the retina. Experimentally proved that intravitreal injection of cryopreserved cord blood derived nuclear cells in rats with a neovascular retinopathy, newly formed vessels have undergone reverse development.

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Files

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diss.doc

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