Zagorodnia L. Features of the pathogenesis of disorders of water-salt metabolism in patients with chronic heart failure and justification of the ways of their correction

In the thesis are the theoretical generalization and solving actual scientific task, dedicated to the study of pathogenetic substantiation of improving the treatment of heart failure with impaired systolic left ventricular function and coronary heart disease and arterial hypertension to study the mechanisms of soil water-salt metabolism and correction of disorders on the background of the basic treatment of heart failure. It is shown that in patients with chronic heart failure with impaired systolic function on the background of ischemic heart disease and hypertension manifest signs cardiorenal syndrome type II in the form of reduced filtration and concentration of kidney function, closely related to violation of left ventricular systolic function, indicating forming cardiorenal syndrome and mutual burdening pathology cardiovascular and chronic kidney disease. When used in the complex treatment of pentoxifylline in 43 (81.1 %) patients managed to reduce the display of signs of congestive heart failure and increase the glomerular filtration rate in 27 (50.9 %) patients reverse the signs of proteinuria. By increasing the speed of glomerular filtration rate there was normalized daily excretion of electrolytes (potassium, sodium and chloride) in 37 (69.3 %) patients. Combined therapy with the use of methylxanthine derivatives improved the exercise tolerance (473.8±6.1) in the performance test of 6-minute walking, improve quality of life, normalize renal functional reserve.