Kozina O. Hemostasis and inflammation in various forms of thromboprophylaxis in abdominal surgery

The thesis is devoted to the actual problem study, research and implementation of best options in the TPF scheduled abdominal surgical interventions. Based on analysis of the survey results and TPF 200 patients with moderate risk were identified TEU changes of hemostasis, inflammatory markers and hemodynamics. All patients awaiting surgery have increased pressure on the heart, hypercoagulable initiation of the inflammatory cascade that increases the risk of TEС. TPF UFH does not eliminate the activation of all levels of coagulation hemostasis 1 postoperative days and the imbalance between inhibition of endogenous anticoagulant and fibrinolytic systems, with the risk of TEС to 5 days. TPF nadroparinum calcium due to normalization of hemostasis balance minimizes the risk of thrombosis and bleeding from 1 postoperative day. TPF enoxaparinum natrium blocks the activation of all levels of coagulation hemostasis, despite the start of preoperative start that by opposing changes in endogenous anticoagulant, along with the absence of anti-inflammatory effects of the drug against the backdrop of the end products of fibrinolysis deficiency increases the risk of bleeding in the perioperative period. TPF bemiparinum natricum provides protection and patient TEС of perioperative bleeding against the backdrop of significant anti-inflammatory effect, which makes it optimal. The presence of vasospasm is correlated with activation of coagulation general way, raising the risk of TEС.