Svidko K. Compensation of limbal stem cell deficiency with cryopreserved cord blood nucleated cells.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U001072

Thesis Registration Form

0416U001072.pdf

Applicant for

Specialization

  • 14.01.35 - Кріомедицина

22-12-2015

Specialized Academic Board

Д 64.242.01

Institute of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine

Essay

The research object were structural and functuional characteristics of rabbit's cornea during experimental corneal limbal defficiency (CLD) and after use of cryopreserved cord blood nucleated cells ( cCBNCs). The research aim was studing the possible use and investigation of the action mechanism of cryopreserved cord blood nucleated cells in experimental model of CLD. Research methods: immunological, cryobiological, histological, clinical and ctatistical analysis. Cryopreservation has been proven to provide a high level 0f cCBNCs preservation, as evidenced by the essessment of structural organisation and functional activity of the cells in vitro anf in vivo. It has been shown that the application of cCBNCs, cryopreserved in the medium with lower content of dextran, has the same therapeutic efficiency. The use of cCBNCs as the therapeutic drug for CLD ensured the recovery of visual function. The results of experimental researches allow the recommending of cCBNCs to treat the CLD in clinics.

Read more

Files

aref.doc

dis.doc

dis.doc

Similar theses

0421U101272

Vlasov Oleksandr Oleksiiovych

Effect of extract of cryopreserved piglet`s skin fragments and fullerene C60 on alterative and regenerative processes in skin after cryodestruction (experimental study)

0421U101128

Vlasov Oleksandr

Effect of extract of cryopreserved piglet`s skin fragments and fullerene C60 on alterative and regenerative processes in skin after cryodestruction (experimental study)

0420U101007

Likhitskyi Oleksii Oleksiyovych

The use of cryopreserved placental tissue for correction of the reparative osteogenesis processes of the lower jaw during an angular fracture with osteoporosis (experimental study)

0420U100468

Aidarova Victoriia Serhiivna

Effect of rhythmic hypothermia and cryopreserved cord blood on structural-functional state of central nervous system of rats with dyscirculatory encephalopathy (experimental study).

0419U003851

Chub Oleg V.

Effect of cryopreserved placental explants on course of postmenopausal dyscirculatory encephalopathy (experimental study)