Shchulipenko L. Pathogenic mechanisms of disregulatory states in transport operators: modelling, classification, formalized recognition

Object - disregulatory state transport operators; goal - to identify major pathogenetic mechanisms of state disregulatory opera-tors of vehicles develop their mathematical model classification and recognition; methods - laboratory, biochemical, cytochemical and instrumental, electro, mathemetic; results - it has been established the transport operators’ disregulatory state is determined in the manner of their pathophysiological significance: ANS sympathetic part activity, the state of catecholamine and purine metabol-ic systems of neurohumoral regulation, the state of affecto-effector interaction of reflex autonomic reactions, stress level and cen-tralization of adaptive responses, and then - the state of neurohumoral and endothelial regulation and activity of the parasympa-thetic part of ANS; it has been systematized and highlighted the major pathogenetic mechanisms formation of the disregulatory states among transport operators, has been described the pathophysiological features depending on their professional experience, proposed the classification of the disregulatory states, which includes 6 grades, and has been proved the pathophysiological identity of each class of these states; for the formalized recognition of the proposed classes of the disregulatory states has been with the suf-ficient accuracy for the preventive examinations and sanitation recommendations against the accidence and, in general, for the dis-tinguishing and the diagnostics of the origin and the development of professionally mediated diseases.