Stoliarchuk O. Correction of oxidative stress in patients suffering from acute pancreatitis (clinical-experimental research).

Object - acute pancreatitis (AP); goal – to establish and prove the effectiveness of pathogenetic correction of oxidative stress in patients with acute pancreatitis; methods – experimental, clinical, laboratory, tool, statistical; results – the first time of proved the fea-sibility of introducing mexidol, ascorbic acid in order to reduce the severity of the histological lesions of the pancreas (pancreatic), reduction of oxidative stress in the prostate tissue, minimizing the suppression activity of glutathione-dependent enzymes in the course of the pathological process; the first time of established that due to the effect of these drugs antihypoxanth implemented the necessary conditions for optimization of reparative processes in the pancreas; first specified pattern changes peroxidation processes and antioxidant defense system (AOS) in the early stages of the disease in relation to the severity of the systemic inflammatory response syndrome (SIRS) and morphological changes in the pancreas in patients with AP; the first time of substantiation of the differentiated approach to the choice of the antioxidant according to the form AP in the treatment of early phase of the disease; it proved that the edematous form of AP use of ascorbic acid in combination with a standardized treatment effect is not inferior to mexidol, while necrotizing pancreatitis benefits mexidol application is to reduce the manifestations of SIRS and less severe depression functional state of glutathione AOC; branch – medicine.