Povhanych-Hrytsiak T. Justification individual approach to the treatment of patients with psoriasis based on the determination of molecular genetic indicators (gene polymorphisms TNF-alfa and MTNFR)

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U000906

Thesis Registration Form

0417U000906.pdf

Applicant for

Specialization

  • 14.01.20 - Шкірні та венеричні хвороби

28-04-2017

Specialized Academic Board

Д 26.613.03

Shupyk National Medical Academy of Postgraduate Education

Essay

The dissertation is devoted to the study of gene polymorphism of TNF-alfa, MTNFR that control basic immunological and metabolic processes in patients with psoriasis. The distribution of genotypes of SNP-308 gene TNF-alfa and SNP-677 gene MTHFR, level of cytokine TNF-alfa, family history in patients with psoriasis. Identified some options alleles and genotypes, combinations of genotypes of TNF-alfa gene and MTHFR, associated with characteristic phenotypic features. Powered theoretical substantiation and new scientific problem solution, which is to improve the efficiency of the treatment of psoriasis by individual approach based on the definition of polymorphic variants of genes TNF-alfa and MTHFR and level of cytokine TNF-alfa.

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Files

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aref.doc

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