Isaikova O. Investigation of the transcranial magnetic stimulation impact on autonomic dysfunction in patients with chronic cerebral ischemia

The thesis is grounded and a positive safety impact of the method of repetitive transcranial magnetic stimulation on the state of the autonomic nervous system in 62 patients with chronic cerebral ischemia in stages subcompensation. It was revealed that the peculiarities of clinical manifestations in subcompensation stage of chronic brain ischemia are light and moderate cognitive impairment and depressive symptoms, and autonomic dysfunction in the form of sympathetic direction of autonomic tone with a predominance of autonomic reactivity and insufficient of autonomic maintenance of activity. We prove that transcranial magnetic stimulation was significantly positive effect on the condition of autonomic tone (p = 0,00046) and autonomic reactivity (p = 0,0002), regardless of gender and age of the patient. The autonomic reactivity influenced repetitive transcranial magnetic stimulation statistically significant in patients with normal sympathicotonia (p = 0,000001), autonomic maintenance of activity influenced repetitive transcranial magnetic stimulation normalized regardless of autonomic tone (p = 0,02), and in patients with normal autonomic reactivity sympathicotonia most pronounced (p = 0,000048). A more pronounced effect on the autonomic disorders in patients in subcompensation stage of chronic brain ischemia provides the use of low-level high-frequency (0.3 T, 20 Hz) repetitive transcranial magnetic stimulation dorsolateral prefrontal cortex on the left compared to the high-intensity low-frequency (1.6 T, 1 Hz) repetitive transcranial magnetic stimulation. In addition, there was a significant positive impact on the state of transcranial magnetic stimulation cognitive function and depressive background of patients. A more pronounced effect on cognitive impairment and depressive symptoms in patients in subcompensation stage of chronic brain ischemia provides the use of low-level high-frequency (0.3 T, 20 Hz) repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex on the left compared to the high-intensity low-frequency (1.6 T, 1 Hz) repetitive transcranial magnetic stimulation. It is shown that the use of transcranial magnetic stimulation in patients with chronic brain ischemia in subcompensation stage is a safe method in compliance with Protocol: 10 sessions of 10 minutes, 1 time per day of low-level high-frequency (0.3 T, 20 Hz) or high-intensity low-frequency (1.6 T, 1 Hz) repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex on the left.