Mokrii V. Pathogenetic role of polymorphism Pro12Ala of peroxisome proliferator-activated receptors gene in disturbance of lipid peroxidation in type 2 diabetes mellitus

Object - gene polymorphism Pro12Ala PPARG with diabetes type 2; goal - to identify pathogenic role of gene polymorphisms Pro12Ala PPARG in breach of lipid peroxidation and antioxidant system in diabetes type 2; methods - biochemical, ELISA,, molecular genetics, statistics; results - intensification of lipid peroxidation and antioxidant system in patients with type 2 diabetes reach a maximum in the first five years of the disease, then the last activity significantly reduced on a background of stable and high rates of blood diene conjugates and malonic dialdehyde; the presence of patients with Ukrainian population 12Pro allele polymorphism association Pro12Ala (rs1801282) gene PPARG the development of diabetes type 2; demonstrated impact polymorphism Pro12Ala pathogenesis violation of lipid peroxidation in the blood of patients with diabetes type 2 and its with duration of disease; proved that Pro12Pro genotype in patients with type 2 diabetes is associated with low activity of catalase; male carriers of this genotype have lower levels of ?-tocopherol; nose Pro12Ala genotype with disease duration of 5-10 years there is a significantly greater tendency to develop oxidative stress (increase in blood diene conjugates, malondialdehyde, catalase activity); availability genotype Pro12Pro causes a statistically significant decrease in catalase activity against the backdrop of significantly high rates of blood diene conjugates and malondialdehyde in patients suffering from diabetes type 2 diabetes over 5 years. 74527452