Butenko O. Fetus arrest of development at prematurely born pregnancy: diagnostics and prophylaxis of perinatal pathology.

Scientific work is devoted to depression of frequency of perinatal complications at pregnant women with fetus arrest of development at prematurely born pregnancy by improvement of diagnostic and treatment-and-prophylactic actions. The role of clinical, ultrasonic, endocrinologic, bacteriological and immunologic changes in pathogenesis of an arrest of development of fetus is established at prematurely born pregnancy. It is shown that development of an arrest of development of fetus happens against disturbances of hormonal dysfunction of placenta and microbiocenosis of sexual ways. The role of changes of concentration of cytokines is analysed: the expressed imbalance of the maintenance of cytokines in cervical slime characterizes high degree of infectious risk at pregnant women against fetus arrest of development at not wearing out, new consistent patterns of level about - and antiinflammatory cytokines (TNF-?, ?-ІNF, IL-I, IL-4) both their prognostic and diagnostic value at these pregnant women are determined. It allowed to dilate available data on pathogenesis of development of placental dysfunction and fetus arrest of development. Need of improvement of treatment-and-prophylactic actions for rising of efficiency of diagnostics and depression of perinatal pathology is scientifically proved at fetus arrest of development against prematurely born pregnancy. The main clinical features of a course of pregnancy and labors, and also perinatal results of delivery at women with fetus arrest of development are established at full-term and prematurely born pregnancy. The technique of early diagnostics of arrest of development of fetus at women is improved and introduced at prematurely born pregnancy on the basis of dynamic studying of clinical-functional, laboratory and microbiological methods of research. Practical references on depression of frequency of perinatal pathology at women with fetus arrest of development are improved and introduced at prematurely born pregnancy on the basis of use of early diagnostics and rational tactics of conducting pregnancy and labors.