Wojtyra M. Synthesis and biological activity of thiazolidine derivatives with pyridine moiety in molecules

The object – reactions of [2+3]-cyclocondensation, hydrolysis, hydrazinolysis, condensation, aminolysis, Knoevenagel reaction and Claisen-Schmidt reaction; the purpose – synthesis of non-condensed thiazolidine derivatives with pyridine moiety for the search potential drugs; methods – organic synthesis, NMR spectroscopy, chromato-mass spectrometry, elemental analysis, X-ray analysis, pharmacological studies, COMPARE analysis; results – under the conditions of [2+3]-cyclocondensation reaction synthesized new group 2-pirydynilamino- and 2-pirydynilmetylenhydrazono-4-metylthiazoles and 4-thiazolidinones, carried out their chemical modification in the reactions of hydrolysis hydrazinolysis, Knoevenagel and Claisen-Schmidt reactions. An effective method was proposed for the synthesis of 5-arylidene-2-benzoyilimino-3-pyridinyl-4-thiazolidinones and structurally related 2-thioxo-4-thiazolidinones and 2,4-thiazolidinediones. For the first time received a series of 5-aminometylenderivativs, pirazolin- pyrrolidine-tiazolidines conjugates based on 3-substituted rhodanines. Perspective derivatives with antitumor, anti-inflammatory, antitrypanosomal and antifibrotic activity; introduced – into scientifically research work and educational processes of the departments of pharmaceutical direction; direction – pharmacy.