Solonovych O. Cognitive functions in patients at the interim and remote periods of mild traumatic brain injury

The thesis presents a summary and a new solution of a topical issue in neurology: establishment of diagnostic criteria for the objectivity of cognitive disorders in patients in the interim and remote periods of mild traumatic brain injury (mTBI) and suggested predictors of cognitive impairments. The research is based on the analysis of clinico-neurological, neurophysiological and neuropsychological (NpsT) examination of 115 patients who suffered from a mTBI the main сlinical group, and 45 sportsmen, who underwent 2-4 mTBI, and 40 apparently healthy volunteers of the same age (the сontrol group). The total number of the people examined was 155, aged between 16 and 42; among them 36 females and 119 males. It was established that in the event of a mTBI, the operative memory, attention and deferred adjustment are the most frequently impaired cognitive functions. It was also demonstrated that anxiety, depression and asthenia have an adverse impact on the course of the recovery period in patients with a mTBI. The result of the neuropsychological examination reliably correlated with increased latency and decreased amplitude of the cognitive evoked potentials (CEP Р300) Therefore, it may be concluded that "NpsT-CEP" method is highly predictive of the presence and intensity of brain function disorders at the interim and remote stages mTBI. The most frequently observed pathological EEG changes in patients after mTBI are strengthening of the beta-activity and slow-wave activity; alpha-rhythm increased frequency and reducted amplitude and inversion.