Rybytska M. Factors of cardiovascular risk and atherosclerosis in patients with type 2 diabetes: diagnostics and prevention

The dissertation is dedicated to the optimizing the prevention of cardiovascular disease in patients with type 2 diabetes through a comprehensive evaluation of traditional and additional factors of cardiovascular risk and severity of atherosclerotic lesion. The prevalence of factors of cardiovascular risk (traditional and additional) in patients with type 2 diabetes, including retroactively, according to medical records was analyzed. Significant impact of traditional and additional risk factors on cardiovascular system in patients with type 2 diabetes was determined. The relationships between the levels of HbA1c, hsCRP, uric acid in serum, duration of type 2 diabetes, SBP and duration of hypertension, BMI, the levels in serum of total cholesterol, LDL cholesterol, atherogenic index, the level on a scale HADS and severity of carotid atherosclerosis in patients type 2 diabetes were studied. The features of commitment of patients with type 2 diabetes to accept drugs and the effect of compliance of those patients to the severity of atherosclerotic lesions were determined. The improvement of program of the prevention of atherosclerosis dependent cardiovascular disease in patients with type 2 diabetes through the use of the pleiotropic effects of atorvastatin and losartan was grounded. The numerical system of risk assessment of asymptomatic constrictive atherosclerotic carotid disease in patients with type 2 diabetes, expressed as a percentage, was developed. That system is allowing to identify the tactics of care of the patients with type 2 diabetes at the stage of primary care, depending on the severity of atherosclerotic lesion for timely and optimal prevention and/or therapeutic treatment.