Awad A. Morph functional heart adaptations in conditions of diabetes mellitus without and against the introduction of alkylselenonaphthyridine (Experimental study)

The thesis is devoted to the study of the effect of alkylselenonephthyridine on the morph functional and biochemical manifestations of diabetic cardiomyopathy in the modeling of streptozotocine diabetes mellitus. In the animals of the control group, the biochemical indices varied widely, and had age (exposition) changes that did not exceed the limits of the physiological norm. When modeling streptozotocine diabetes mellitus in the blood serum, the level of glucose and fructosamine increased. Oxidative stress was formed, which initiated an increase, and with increasing exposure of the experiment, a decrease in the activity of catalase and the level of ceruloplasmin. The activity of lactate dehydrogenase and aminotransferases (mostly aspartate aminotransferase, which initiated the growth of the De Ritis coefficient) increased. The ratio of the lipid complex was changed: the level of high-density lipoproteins decreased against the background of an increase in the level of total cholesterol, triglycerides, and low and very low density lipoproteins. When modeling streptozotocine diabetes mellitus against the background of the introduction of alkylselenonaphthyridine, the biochemical parameters after the 60-day exposure of the experiment differed from the indices determined in animals with the streptozotocine sugar diabetes model without the introduction of alkylselenonephthyridine: the glucose level was lowered. and fructosamine by 12.6 ± 0.04% and by 11.2 ± 0.04%, the coefficient of De Ritis by 0.36 ± 0.17 cu. (by 30.2 ± 0.03%), the activity of lactate dehydrogenase by 15.28 ± 4.20%, the total cholesterol and triglyceride levels by 11.4 ± 0.112% and 19.24 ± 0.172%, the low-density lipoproteins and very low density - by 17.70 ± 0.160% and 17.98 ±%, respectively. The level of high-density lipoproteins increased by 4.29 ± 0.047%. The development of streptozotocine diabetes mellitus was accompanied by oxidative stress, as evidenced by depression of antioxidants, dyslipidemia and tissue destruction. The dynamics of morph functional and biochemical indicators was classified as a manifestation of diabetic cardiomyopathy. The introduction of alkylselenonaphthyridine in the modeling of streptozotocine diabetes mellitus increased the antioxidant defense of the body and heart, having a positive effect on morph functional and biochemical indices.