Honta R. Diagnostics and prevention of manifested and threatening thrombotic complications after caesarean section

On the basis of risk factors in the regional perinatal center of Odessa Regional Hospital 550 pregnant women in the term of pregnancy 30-40 weeks were interviewed, questionnaired and examinated. In 6,4% of women we didn't revealed the risk of pulmonary embolism, 42,2% of women had low risk of thrombosis, 57,8% of patients had moderate and the highest risk. Analysis of dynamics of the hemostasiogram indicators in 100 pregnant women with moderate and high risk of thrombosis which received bemiparin and NSAIDs after Cesarean section revealed significant changes in postoperative period which indicate the hypercoagulation on the 5th; 7th days that require a further correc; tive therapy on the outpatient stage. The testing for hemostasis genetic factors was conduct; ed in 30 patients with placental and central or peripheral veins throm; bosis that clinically manifested by severe preeclampsia, intrauterine growth restriction, premature detachment of normally situated placen; ta, venous thrombosis during pregnancy and after delivery. We detect; ed С677Т polymorphism of MTHFR gene in 33.3% of women, F5 G1691A - in 23.3%, F1 G455A - in 36.7%, mutations of PAI1 gene - in 100%, ACE gene - in 60%, ITGB gene - in 40%. In majority of observed cases mutations of different genes were combined. In all women complications developed on a background of risk.