Luta O. Pathogenetic peculiarities of functional, metabolic and morphological disorders of heart in the dynamics of acute lung injury. – Qualifying scientific work on the rights of manuscript

The object - pathogenetic features of the development of metabolic, functional and morphological disorders in the heart in conditions of acute lung injury; the purpose - to find out the pathogenetic features of functional, metabolic and morphological disorders of the heart in the dynamics of acute lung injury; methods - experimental; biochemicals; immune enzyme; functional; morphological; mathematical and statistical; the results - it is shown that simulation of acute lung injury by intracutaneous administration of 0.1 N chloride solution causes activation of lipid peroxidation processes in the myocardium, indicating a significant increase in the content of reagents to thyobarbituric acid with a maximum after 24 hours of experiment. The domination of the prooxidant mechanisms in the myocardium occurs on the background of a violation of the enzymatic level of antioxidant defense - the decrease in superoxide dismutase activity after 12 hours, the activity of catalase and the content of compounds with SH groups - after 48 hours of experiment, as well as the intensification of endogenous intoxication with the maximum accumulation in this period molecules with an average mass fraction of 254 and 280 nm and an increase in the erythrocytic index of intoxication. 24 hours after the introduction of chloride acid, increased dysimunoglobulinemia and accumulation of circulating immune complexes. In the dynamics of acute lung damage after 48 hours, there was a significant violation of the integral rheogram values of the body: decreased pulse blood flow, increased resistance of arterial vessels, increased venous outflow, as well as decreased shock and heart rate. Under these conditions, wave-like deviations of heart rate regulation with predominance of adrenergic effects and centralization of regulation after 12 and 72 h after intracutaneous administration of 0.1 N hydrochloric acid are characteristic. 24 hours after the modeling of acute lung injury, the area of the endocardial surface of the left and right ventricles of the heart significantly decreases with subsequent growth in the left ventricle - up to 48 hours, in the right side - up to 72 hours, indicating a compensatory enhancement of the pump function due to stretching of the muscle fibers . The revealed violations in the myocardium are associated with the formation of cellular infiltrates of the stroma, an increase in the phenomena of paresis in small vessels, erythrostheses, edema of the stroma, focal dystrophic changes in cardiomyocytes, which increase up to 72 h at the expense of erythrotic and plasmapostases, hyperextension, fiber fragmentation and their focal wave deformation.