The dissertation reveals new aspects of the pathogenetic mechanisms of fumonisinotoxicosis in animals and poultry, in particular, the influence of fumonisins on the state of protective systems of the organism of animals has been established. The dynamics of the physiological state of the organism, metabolism, activity of enzymes in the blood of rats and hens in the development of fumonisinotoxicosis was studied. The average mortality rate of fumonisins in laboratory rats was first established. Based on the determination of the acute toxicity of fumonisins for intragastric administration to white rats, it was found that DL50 fumonisins according to Shtabskyi were 845.0 (546.3 ÷ 1143.7) mg/kg of body weight, according to G. Kerber 883.33 mg/kg. Based on the received characteristics of fumonisins, according to international requirements for toxicity testing, the degree of danger and systematization of results, according to the classification and scale of toxicity, is classified as «moderate toxic substances». An effective scheme of for laying hens treatment and prevention of fumonisinotoxicosis has been developed. The pharmacotoxicological action and therapeutic effectiveness of HamecoTox action on the organism of laboratory animals and chickens for fumonisinotoxicosis was theoretically substantiated and practically proven. It was established that addition of HamecoTox to the fodder reduces the negative effect of fumonisins on the organism of animals, normalizes under these conditions morphological and biochemical parameters of blood, immune and antioxidant status of the organism of experimental animals. It is especially important to note the stabilization of hematological parameters, the content of hematocrit, the number of leukocytes, and the increase in the content of eosinophils and lymphocytes, which reflects the activation of hematopoiesis in the organism of experimental animals and its protective factors after application of feed additives of HamecoTox and Zeolit under the conditions of fumonisinotoxicosis. An increase in the urea content in these groups indicates the restoration of the synthesis and excretory function of the liver. We distinguish that the effectiveness of feed supplement Zeolite is slightly inferior to HamecoTox. The expediency of using HamecoTox for chickens was scientifically substantiated and experimentally confirmed. It has been established that HamecoTox, which was used for chickens-feeders with feed for 21 days for the withdrawal of fumonisins, greatly reduces the negative effect of fumonisins and thus, reduces their level in the bird organism, which is expressed in stabilizing biochemical parameters and productive qualities. Under the conditions of spontaneous fumonisinotoxicosis in poultry, an additional introduction of HamecoTox to laying hens for 21 days contributed to the normalization of the morphological and biochemical parameters of blood of experimental birds, as well as to the increase of the antioxidant and immune status of the chickens body. It was determined the increased activity of catalase by 22 %, superoxide dismutase by 29 %, glutathione peroxidase by 7 %, and reduction of primary, secondary and end products of LPP, respectively, by 25, 24.5 and 13 %, relative to indicators of diseased poultry. We recommend that the fodder additive HamecoTox for the prevention of fumonisinotoxicosis, contaminated with mycotoxins, should be fed at a dose of 4 kg / t feed. The scientific novelty of the obtained results is confirmed by the declarative patent for utility model No. 122203, Ukraine, IPC 2017.1 А61D7 / 00 «Method of correction of indicators of antioxidant system of animals under conditions of fumonisinotoxicosis». Declared 07/11/2017. Published 12/26/2017. Bull No. 24
