Bula N. The role of hydrogen sulfide in mechanisms of esophageal mucosa cytoprotection

For the first time, the mechanisms of cytoprotection of the esophageal mucus barrier in the aspect of the physiological role of hydrogen sulfide (H2S) under physiological conditions and on models of non-erosive and medicated esophagitis induced by cytotoxic influence of tetrachloromethane, high-calorie high-carbohydrate nutrition, inhibition of activity of H2S/cystathionine-?-lyase, H2S/cystathionine-?-synthase systems, NSAIDs for simulating biosynthesis of eicosanoids and the use of H2S-associated NSAIDs by structural and functional changes of their barrier function in the esophagus, hematocrit performance, containing of GCP-2, IL-6, IL-10, IL-17. It is proved that the development of non-erosive esophagitis is associated with the action of H2S. It has been shown that H2S-associated NSAIDs have an esophagoprotective and protective effect on the barrier function of EM and manifestations of anti-inflammatory properties, in contrast to the effects of classical NSAIDs, which suggests the feasibility of their further preclinical and clinical studies.