Deriyenko T. Features of drug support of patients with arterial hypertension after implantation of the cardiac pacemaker.

This thesis is devoted to establish the characteristics of changes in the degree of arterial hypertension (AH) and their importance in pharmacological support of patients with permanent pacemakers. Before the implantation 1degree AH was found in 9%, 2 degree AH - in 54%, 3 degree AH - in 37%. At the annual stage of pacing, drug optimization contributed to an increase in the concentration of patients in the group of 1degree of AH, due to reduction in groups 2 and 3 degree of AH and achievement of the target level of BP in the group of patients. At the annual stage, after the implantation of cardiac pacemaker in patients with AH, optimization of drug therapy contributed to a decrease in systolic blood pressure (SBP) and diastolic systolic blood pressure (DBP), a decrease in the end systolic and diastolic volume and an increase in ejection fraction of LV. It was noted that at the annual stage of observation in 74% of patients in DDD / DDDR stimulation, it was necessary to increase the AV-delay of the stimulated and detected complex, to a greater extent at AH 2 and 3 degree. It was shown that in patients who reqired an increase in the AV-delay of the stimulated and detected complex, there was an increase in SBP by 9%, and DBP by 5%, which requires strengthening of antihypertensive therapy. During the annual follow-up period, anti-hypertensive therapy in patients with DDD / DDDR stimulation had a significantly higher decrease in SBP and DBP compared to VVI / VVIR, regardless of the degree of hypertension.