Minina O. Proliferative processes of endometrium at women in postmenopause: optimization of diagnostics, treatment and rehabilitation.

Dissertation work is devoted to rising of efficiency of diagnostics and treatment of proliferative processes an endometrium at women of post-menopausal age on the basis of improvement and introduction of algorithm of diagnostic, treatment-and-prophylactic and rehabilitational actions. New aspects of pathogenesis of proliferative processes an endometrium at women of various post-menopausal age who consist that development of polyps the endometrium at patients is more senior than 60 years are presented is accompanied by changes of parameters of steroid reception in mononuclear fraction of blood cells. These changes concern only alternative type of steroid receptors, associated with protein: MER and Рr-7. Hyperplasia development an endometrium at patients in the period of postmenopause is accompanied by changes of an expression of receptors of sexual steroids in mononuclear fraction of blood cells. Thus, multidirectional changes of reception of steroids - estrogen depression (MER and ERp) are observed irrespective of age of patients, when rising an expression of receptors of Progesteronum (PR- ). The received results allowed to prove scientifically need of optimization of diagnostics, treatment and reabilitation of women of this group. Tactics of low-invasive expeditious treatment of the given pathology on the basis of the differentiated approach to hysterorezectoscopia and abliation use an endometrium is optimized. Tactics of rehabilitational therapy at women of various post-menopausal age after expeditious treatment of proliferative processes an endometrium taking into account an expression of receptors of sexual steroids in mononuclear fraction of blood cells is offered.