Mushak N. . Improvement of prevention of obstetric complications in pregnant women with primary arterial hypertension in conditions of endemic iodine deficiency.

The scientific work is devoted to solving the current issue of modern obstetrics - reducing the frequency of obstetric and perinatal complications in pregnant women with primary hypertension in conditions of endemic iodine deficiency on the basis of studying the functional state of the thyroid gland, the fetoplacental complex, anamnestic, clinical and laboratory and biochemical diagnostic methods and introduction of the preventive and therapeutic measures complex. There is a tendency to decrease the thyroid hormones content in pregnant women with low levels of hormones, indicating a correlation between levels of hormones of fetoplacental complex and thyroid gland. The scientific data on the features of the state of peroxide oxidation of lipids, the system of antioxidant defense and hemostasis in these pregnant women and their influence on the development of placental dysfunction have been supplemented. For the first time it has been proved that during pregnancy with primary arterial hypertension (PAH) against the background of iodine deficiency placental dysfunction appears violations of the hormonal function of the placenta from early pregnancy, primary disorders of hemodynamics are formed in the utero-placental lobe, which negatively affects the condition of the fetus and leads to the development of developmental delay and distress of the fetus. In pregnant women with PAH against the background of natural iodine deficiency, it is suggested to conduct a dynamic ultrasound-fetoplacetometry during pregnancy for the purpose of early diagnosis of disorders in the mother-placenta-fetus. The method of prevention of violations in the system of mother-placenta-fetus in these pregnant women has been developed, which allowed to ensure the proper formation and functioning of the fetoplacental complex, which contributed to the reduction of obstetric and perinatal pathology in pregnant women with PAH against the background of natural iodine deficiency. The results of the study allowed us to scientifically substantiate the differential complex of diagnostic and treatment-preventive measures for the prevention of obstetric and perinatal complications in pregnant women with PAH against the background of natural iodine deficiency, their implementation allowed to significantly reduce the frequency of development of early gestosis 1.8 times, gestational anemia in 1.9 times, premature childbirth by 2.6 times, placental dysfunction by 2.8 times, syndrome of FGR in 1.8 times, fetal distress in 2.4 times, combined preeclampsia of 2 times, Caesarean section 2 times.