Hryshchuk Y. Optimization of surgical treatment of abdominal wall hernias by selecting adequate biocompatible allograft using nanobiosensor technology

On the base of complex interdisciplinary study found that practical all mesh for hernioplasty which are in use today, are aggressively effected by recipients body that resulted in local aseptic inflammation and affects the quality of life of operated. Established that the method of mesh compatibility testing to recipient's body is to measure the affinity interaction forces between the implant's surface and patient's immunoglobulin G (IgG) using as a tool an atomic force microscope. It is shown that this method is sensitive and can recognize surface material, which differs only in the made of the implant manufacture. The correlation of patients' clinical manifestations who undergo hernioplasty and affinity forces between the implant's surface and one's immunoglobulin G (IgG). It is shown that the strength of affinity interaction is an individual index and can be divided by the value and clinical manifestations into 3 groups: unlikely risk of complications; probable risk of complications and risk group. It is shown that in practice the use of results AFM-testing has reduced the risk of complications such as aseptic local inflammation in 2 times from 12.8 % to 6 %. Application of Adapting composition (AC) on the implant's surface just before surgery also prevents body reactions to it and minimizes the time of wound healing.