In the framework of the dissertation, the study of the process of registration, content and practical implementation of Germany's policy on Central and Eastern Europe during the Chancellery of Angela Merkel has been conducted. The possibilities of German activity in the region are studied, as well as the main dimensions of interaction. The end of the Cold War, the collapse of the socialist system, and the emergence of new independent countries in Europe resulted in revision of the Germany’s foreign policy concept. An effective political strategy and support for European integration processes allowed Germany to become the key "locomotive" of the EU and an important figure in the international relations system. The use of non-military means to achieve political goals and objectives is a decisive feature of the foreign policy strategy of the Federal Republic of Germany. It involves active multilateral and bilateral cooperation, orientation in international relations on common interests and values. European politics remains traditionally the main focus of German diplomacy, despite the rapid changes in the international environment, the emergence of new threats and challenges. From the interests of the Federal Republic of Germany for further strengthening of the EU there is a direct interest in the creation of a unified security system on the territory of Europe and the presence of stable states on its borders. This problem was especially relevant after the annexation of the Crimea and Russia's open aggression against Ukraine from 2014. The concern of the CEE countries regarding the possible escalation of the conflict could lead to a convergence of their positions with the German. The thesis for the first time in Ukrainian international political science has been devoted to the issue of the evolution of the "Eastern policy" of the Federal Republic of Germany after the accession of Central European countries and part of the Balkan countries to NATO and the EU. The question of the difference in attitude of Germany to the countries of Central Europe and the East European countries of the post-Soviet space is raised. On the basis of the analysis, the stages of the reaction of German foreign policy to the events of the military annexation of Crimea to Russia and the conflict in the East of Ukraine were determined. An analysis of the evolution of German relations with the countries of the Visegrad Group in the European integration and the possibilities of applicating the experience of these states in defining the foreign policy of Ukraine in the field of bilateral relations with Germany on realization of the European integration perspective of our state. The theoretical approaches to the study of German foreign policy towards Central and Eastern European countries during the Chancellery of Angela Merkel have been improved. The peculiarities of the process of the transformation of the foreign policy of the Federal Republic of Germany towards the states of the CEE, which is manifested in the reorientation from the usual behavior of the "moderate observer" to the role of "anti-crisis manager", is specified. The significance of the Weimar Triangle from the point of view of the Federal Republic of Germany’s development of the foreign policy’s eastern vector, which consists in the further expansion of the EU towards the East and the formation of a single European security system. The main directions and tasks of the relationship between the Federal Republic of Germany and the countries of the Visegrad Group, aimed at strengthening support in the EU, in view of the long-term crisis in the European Union, the change of the US approaches to the problems of international and, in particular, European policy and strengthening of Russia, have been studied. The interest of Federal Republic of Germany is about further strengthening of the EU, based on the creation of European unified security system on its territory and the presence of stable states on its borders. This problem become significant especially after the Crimea annexation and Russia's aggression against Ukraine since 2014. Due to possible escalation of the conflict, the CEE countries concern, could lead their convergence positions with the German. Scientific materials and conclusions of the dissertation can be useful for the work of analytical institutes and research centers, as well as the development and preparation of study materials for higher education institutions, regular and special courses of "International relations and world politics", "Foreign policy of Germany", "Foreign Policy of Western European Countries".