Object – defects of the abdominal wall in elderly and senile patients; goal – improvement of the results of surgical treatment of abdominal wall defects in elderly and senile patients who developed both during involutionary processes and as a result of surgical diseases of the abdominal wall and abdominal organs based on their study of topographic, anatomical and pathological changes and the development of optimal methods for their corrections; methods – general clinical, laboratory, instrumental, morphological, statistical; results – for the first time, regularities of topographic and anatomical changes of the abdominal wall in elderly and senile patients were established in the form of their restructuring; for the first time, the dynamics of increasing the number of mutation processes during the genesis of the elastic structure of the connective tissue with age; expanded scientific data in the pathological study of age-related changes in the muscles of the abdominal wall in elderly and senile patients; it has been proven that age-related degenerative changes in muscles and aponeurosis can predictively lead to the appearance of abdominal wall defects and is one of the causes of relapse after surgical intervention; for the first time, it has been experimentally proved that a polypropylene mesh with a one-sided anti-adhesive gel coating (oxycellulose) when implanted into the abdominal cavity creates strong bonds with the fatty tissue of the greater omentum in the absence of alternative changes in the implant itself, and the gel coating of the free surface of the implant prevents adhesions from surrounding abdominal organs cavity, but retains "inflammatory readiness" for at least three months; for the first time a method of using xenocide as an implant for the temporary closure of the abdominal cavity during eventration and strangulated ventral hernias in conditions of purulent peritonitis was developed; for the first time it was proved that with age, the sexual characteristics of the inguinal area are leveled, which allows to predict the development of a hernia in both articles equally; for the first time with inguinal hernias with a large defect in the posterior inguinal wall in elderly and senile patients, it is reasonable to perform an inguinal canal aloplasty using a polypropylene implant in combination with an aponeurosis, which together gives more strength and reduces the likelihood of relapse; for the first time, developed an algorithm for predicting postoperative locally inflammatory complications in the area of postoperative wounds in hernioplasty, based on such model predictors: pathology, age, gender, obesity, abdominal wall defect sizes, aloplasty method, duration of operation, type of drainage; proved the effectiveness of using the developed probe for drainage and enteral nutrition in the early postoperative period with strangulated postoperative hernia, which reduced the postoperative period due to early rehabilitation of patients, as well as reduce the frequency of postoperative complications; branch – medicine.
