Levytskiy I. Experimental substantiation of methods of pathogenetic copification of rehmathogenic retinal detachment

Object - rhmathogenic detachment of the retina of the eye; the aim is to determine the main pathophysiological mechanisms of the pathogenesis of experimental rhmathogenic retinal detachment and to develop experimentally substantiated methods of its correction; methods - pathophysiological, biochemical, ophthalmological, statistical; results - endothelial dysfunction is proven to be an important link in the pathogenesis of experimental rhymatogenic retinal detachment. In the studied pathology, the content of the Villebrand factor increased by 8.3 % and endothelin-1 by 16.1 %, and the level of S-nitrosothiols decreased by 26.3 % in the blood of the experimental animals. The most characteristic changes were detected at the 21st day. It has been established that in the mechanisms of endothelial dysfunction enhancement during rhymatogenic retinal detachment the development of inflammation is involved, which is confirmed by an increase in Interleukin-1β production by 19.0 % and inducible synthase by 44.4% in the blood of experimental animals. It was shown that the activity of succinate dehydrogenase and malate dehydrogenase was reduced in the experimental group without correction by 48.3 % and 38.7 % respectively in the ganglionic layer, and 46.3 % and 41.4 % in the vasculature, and the administration of L-arginine , cyticoline and D-asparagine is observed restores their activity to the values of intact animals.Corrective effect of the complex application of the effect of cyticoline, D-asparagine and L-arginine on different stages of the pathogenesis of rhmathogenic retinal detachment in the experiment has been established. 48 % of operated patients about rhegmatogenous retinal detachment, in the presence of complete anatomical fit of the retina, revealed changes in the form of: residual detachment detachment of neurosensory epithelium, presence of diffuse or cystic macular edema, clinically manifested by low visual acuity and the presence of metamorphoscopy. Appliance of citicoline in the early postoperative period contributed to the clinical recovery of 62% patients in the main group, which was 2.6 times more than in the control group, while the quality of vision in patients with the main group was significantly better, as evidenced by the absence of complaints about metamorphopsia in 48% of patients compared with 21% of control patients. It was established that after 6 months in patients who received in the postoperative period a nootropic cyticoline drug, which leads to increased electrical sensitivity of the retina and optic nerve.