Sharipov R. Alterations of cardiohemodynamics under focal cerebral ischemia-reperfusion and their correction

The dissertation is devoted to the study of disorders of cardiohemodynamics under conditions of focal cerebral ischemia and reperfusion occured during the pathogenesis of ischemic stroke, such as cerebrocardial syndrome. In the dissertation, focal cerebral ischemia-reperfusion was simulated using a 60-minute occlusion of the middle cerebral artery in rats. Disturbances of systolic and diastolic function of the heart were revealed during both ischemia and reperfusion. In animals during ischemia, the indicators of pumping and contractile function of the left ventricle decreased, the processes of relaxation of the myocardium were disturbed. Similar disturbances were observed during reperfusion, especially in the early period - up to 30 min. After 24 hours, a partial recovery of indicators and even an increase in stroke volume and minute blood volume (cardiac output) were detected. The ways of correction of cardiac function were proposed. In vivo combined administration of DL-propargylglycine and L-cysteine resulted to an increase in animal survival 24 hours after focal cerebral ischemia-reperfusion, promoted preservation of indicators of pumping function of the heart, prevented diastolic dysfunction and improved the processes of relaxation of the left ventricle. Following administration of the above compounds, the manifestations of oxidative-nitrosative stress in the heart triggered by focal cerebral ischemia with subsequent reperfusion were decreased. In animals treated with ecdysterone for 18 days prior to focal cerebral ischemia-reperfusion, the manifestations of oxidative and nitrosative stress in the heart mitochondria were significantly reduced. The results obtained can be used to prevent and correct the cardiohemodynamic disorders that occur in patients during ischemic stroke and reperfusion following cerebral ischemia as a complication of thrombolysis, one of the current methods of treatment of this pathology.