Prodan T. Optimization of results of assisted reproductive technology programs in protocols of oocyte donation

The aim of the study was to increase the effectiveness of infertility treatment in reproductive age women with reduced ovarian reserve by optimizing oocyte donor stimulation protocols and methods for preparing patients for the in vitro fertilization program. Was carried out a retrospective clinical and statistical analysis of the results of oocyte donors stimulation for the selection of the optimal protocol. Was studied the quality of oocytes obtained in donation programs Have been determined the state of endometrial blood supply in women with reduced ovarian reserve and the effect of endometrial scratching on it. Was developed, implemented and evaluated the effectiveness of the method of infertility treatment in reproductive age women with reduced ovarian reserve. Was shown that the use of gonadotropin-releasing hormone agonists in oocyte donors lead to increasing the duration of stimulation, the amount of FSH used, with a parallel decrease in the number of oocytes obtained and their quality. It was proven that the use of corypholitropin alpha in oocyte donation programs is more justified due to the possibility of obtaining more morphologically high-quality mature oocytes and more convenience of the specified stimulation protocol for donors. It was revealed that the overall assessment of the quality of life in connection with treatment and the subjective assessment of the convenience of treatment are higher, and the fear of the need for daily injections is lower when using corypholitropin beta. Developed approach to the treatment of women with reduced ovarian reserve was introduced into practice. It was shown that in patients treated according to the developed method the endometrial blood supply improved; and it allowed to increase the effectiveness of infertility treatment in women with reduced ovarian reserve in oocyte donation programs: increased the pregnancy rate by 23,33% and live births by 26,67%; reduced the level of reproductive losses by 2-3 times.