Parubina D. Features of genital organs microbiocenosis correction in women of reproductive age suffering from uterine leiomyoma

The estimation in the dissertation work of the problem of the vaginal biocenosis of women of reproductive age, patients with uterine leiomyoma, which affects on the general condition of the organism, clinical course of the main and accompanying diseases, is carried out. An important role belongs to the detection of extragenital pathology, accompanying gynecological diseases, evaluation of generative, reproductive functions, risk factors for uterine fibroids. Ultrasonic examination of leiomatous nodes in women of reproductive age was introduced to determine inflammatory changes in their tissues. A scheme for correcting the biocenosis of the urogenital tract, the organism of women of reproductive age, patients with uterine leiomyoma and their regular sexual partners has been developed and introduced. The use of an improved algorithm for the management of patients of reproductive age, patients with uterine leiomyoma, on the basis of the results of treatment after 1 year, promoted an increase in the frequency of "normocoenosis" (by 34.7%; p <0.001), "intermediate type" (by 5.6%; p <0.001), a decrease in the frequency of "dysbiosis" (by 77.8%; p <0.001), "vaginitis" (by 95.1%; p <0.001), exocervicitis with cervix uteri erosion (by 21.2%; p <0.001), posthemorrhagic anemia (by 16.8%; p <0.001), hyperpolymenorrhea (by 18.8%; p <0.001), discomfort in the lower abdomen (by 21.7%; p<0.001), pelvic pain, lower abdomen gravity (by 13.1%; p <0.05), radiculal syndrom (by 12.3%; p <0.05), frequent urination (by 8.5%; p <0.05). The use of probiotics during menstruation, before and after etiotropic therapy, and also to regular sexual partners of women of reproductive age, with leiomyoma patients, led to genuinely positive results at 1, 3 months and 1 year. There was an increase in the frequency of normalization of the vaginal biocenosis "normocinosis", "intermediate" type of smear, a decrease in the frequency of "dysbiosis", "vaginitis", a decrease in the frequency and severity of concomitant gynecological diseases, pain syndrome.