Yalovenko M. Prediction of the development of permanent atrial fibrillation and hospitalization in patients with stable coronary artery disease in combination with arterial hypertension

The dissertation is devoted to the improvement of approaches to the diagnosis, treatment and prognosis of the development of permanent form of atrial fibrillation (AF) and risk assessment of hospitalizations in patients with stable coronary artery disease (CAD) in combination with arterial hypertension (AH) based on the determination of clinical features, the state of cardiac remodeling, the systemic inflammation markers activity, as well as to the increase the basic therapy effectiveness with the addition of L-arginine. The most informative of the inflammatory markers, which effect the development of a permanent AF in patients with stable CAD and AH, were established to be the levels of high sensitive-CRP, interleukin-1β and interleukin-10. The developed prognostic models allow to stratify patients into the risk groups and to calculate the development probability of constant form of AF at the individual level taking into account a functional class of stable CAD, a left atrium linear size, an ejection fraction of the left ventricle, a cholesterol of low density lipoprotein, an interventricular septum thickness, the markers of systemic inflammation, highly sensitive CRP and interleukin-1β. The factors that increase the probability of patient’s hospitalization with permanent AF, stable CAD in combination with AH for 12 months were established. The prescription of exogenous L-arginine as part of basic treatment for 12 months in patients with permanent AF, CAD and AH is proved to have significant hypolipidemic and anti-ischemic effects.