Orlovskyi D. The assessment of long-term results of draining and resection-draining methods of surgical interventions into complicated forms of chronic pancreatitis

As a result of a complex analysis of laboratory and instrumental data in the long term postoperative period, the objectified advantages of resection and draining operations over the pancreatodigestive were obtained. For the first time, variants of pancreatic pathology were grouped into long-term postoperative follow-up and it was shown that their presence was much more frequently observed in patients after performing pancreatoimostomy compared with patients undergone resection-draining operations. It is noted that impaired digestion and absorption of lipids, glucose and proteins, as well as a decrease in the secretory function of β-cells of the pancreas is appropriate(characteristic) to the patients with intra-draining surgery. It has been found that the patients after draining operations in the long term, the excessive activation of proinflammatory cytokines was noted , which can contribute to the further progression and chronicity of the inflammatory process and causes an increase in the development of fibrosis processes in the pancreas. Using the methods of regression analysis, the prediction of the development of fibrosis of the pancreas is made according to the shear wave elastography in the distant period, the criteria for the formation of the risk group of adverse results of surgical interventions on the pancreas are developed. According to the results of the study, a new way of diagnosing of digestive disorders in the distant period after surgery on the pancreas of complicated forms of chronic pancreatitis was developed and implemented into clinical practice.