The object of research: processes of immunophysiological adaptation of rats and piglets' body with the development of oxidative stress on the background of complex drugs.
The purpose: to elucidate the mechanisms of formation and regulation of immunophysiological adaptation and antioxidant defense system of rats and piglets with the development of oxidative stress on the background of the use of complex drugs.
Research methods: hematological (morphological, biochemical); zootechnical (intensity of growth and development of young animals); statistical (processing of research results).
Scientific novelty: a systematic study of the immunohistological state and antioxidant defense system of rats and piglets under oxidative stress and differences in the mechanisms that reflect the development of adaptation syndrome with the combined use of vitamins A, D3, E in the form of a liposomal emulsion and feed additive was conducted for the first time. The functional relationship between the intensity of lipid peroxidation processes, the antioxidant defense system's activity, and the immune potential of weaned piglets under conditions of vitamins A, D3, E, ground fruits of milk thistle, selenium, and methionine in the supplement to the combo feed was substantiated. Alimentation animals feed additive "Butaselmevit-plus" in the nutrition helps prevent the development of oxidative stress in piglets during weaning, as indicated by lipid peroxidation and antioxidant indicators system. It is proved that the feed additive "Butaselmevit-plus" in piglets increases their resistance due to the influence of its components on the activation of the antioxidant defense system, the immune system, and the suppression of lipid peroxidation.
Three patents of Ukraine confirmed the scientific novelty of the obtained results for a utility model: № 106773, 112676, 126687. The technical specifications of Ukraine for the liposomal drug "Butaselmevit" and the feed additive "Butaselmevit-plus" were obtained.
Proposed: to increase the adaptive capacity of the body of piglets at an early age at weaning and prevention of oxidative stress, to further maintain during rearing and fattening, it is recommended to use feed additive "Butaselmevit-plus" in the amount of 100 mg/kg body weight per day with concentrates of a diet in the period from 21 to 40 days of age.
Implemented: Scientific developments have been implemented in the farm of Zakarpattia region, Tyachiv district "New level 2006" p. Tyachivka and farms of the Zakarpattia region of the Mukachevo district of LLC Koshet Chopivtsi.
Based on theoretical generalizations and research, Butaselmevit-Plus feed additive for piglets has been developed and put into practice to increase the body's adaptive capacity, increase weight gain, and strengthen their bodies' protective systems during weaning. A new complex liposomal preparation based on milk thistle, butaphosphane, methionine, selenium, vitamins A, D3, and E to prevent toxic liver damage in animals has been developed.
The obtained results allowed to deepen the knowledge about the pathogenetic mechanisms of oxidative stress and on this basis to develop more effective methods of correction of the detected disorders.
The obtained data are used in the educational process at Stepan Gzhytskyi National Univesity of Veterinary Medicine and Biotechnologies, Lviv; they are recommended for introduction into the curriculum of a number of disciplines at the faculties of veterinary medicine and biological faculties of higher education in Ukraine.
